The Portuguese fails to make the squad for the match at the Etihad Stadium after picking up an injury.
The 37-year-old is United’s top scorer this season with 15 goals in 30 appearances across all competitions, though Gary Neville insists it is not a big loss for Ralf Rangnick
“Manchester United have been playing on the counter attack [at Manchester City in recent years],” Neville told Sky Sports. “United over the last three or four years have been a counter-attacking team, punching out through Rashford and others on the break.
“Cristiano not being in the team, you’d never say it’s a positive, but I don’t see it as a big loss you might see it in other games, because I think on the counter attack, Manchester United need to be dangerous today, and they’re better off with Rashford up front than Cristiano.”
Man City XI: Ederson, Walker, Laporte, João Cancelo, Stones, Rodri, Grealish, De Bruyne(c), Bernardo Silva, Foden, Mahrez.
Subs: Luiz Rosa, Zinchenko, Carson, Mbete, McAtee, de Jesus, Delap, Gündogan, Sterling
Man United XI: De Gea; Wan-Bissaka, Lindelof, Maguire, Telles; McTominay, Fred, Pogba; Fernandes, Sancho, Elanga
Subs: Rashford, Jones, Mata, Henderson, Matic, Bailly, Mejbri, Diogo Dalot, Lingard